Bipolar Disorders: Basic Mechanisms and Therapeutic by Jair C. Soares, Allan H. Young

By Jair C. Soares, Allan H. Young

Responding to the explosion of study at the pathophysiology and administration of bipolar illness, this thoroughly revised moment variation spans uncomplicated mechanisms, neuroimaging, viral etiology, neurofactors, present remedy implications, and smooth theories of the neurobiology of bipolar illness to face because the such a lot authoritative reference in this debilitating situation. Written and edited through the world over lauded specialists within the box, this resource covers an expansive array of subject matters together with genetic and causal elements, neuroendocrinology, neurotransmitters and sign transduction pathways, neuroimaging and neurorecognition, and clients for brand new therapy improvement.

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Extra info for Bipolar Disorders: Basic Mechanisms and Therapeutic Implications, 2nd edition (Medical Psychiatry)

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The mood spectrum in unipolar and bipolar disorder: arguments for a unitary approach. Am J Psychiatry 2004; 161:1264– 1269. 64. Angst J, Cassano G. The mood spectrum: improving the diagnosis of bipolar disorder. Bipolar Disord 2005; 7(suppl 4):4 –12. 65. Dunner DL. Clinical consequences of under-recognized bipolar spectrum disorder. Bipolar Disorders 2003; 5:456–463. 66. Baldessarini RJ. A plea for the integrity of the bipolar disorder concept. Bipolar disorders 2000; 2:3 –7. 67. Judd LL, Akiskal HS.

Yet, it is now clear that with the recent major developments in molecular and genetic methodologies and brain imaging techniques, the available models cannot adequately respond to the new challenges (52,76). It is now the time for behavioral scientists to make a major effort, possibly combining all the approaches discussed above, to detect, create, and validate new models that may provide better and more adequate tools to further the research of bipolar disorder. REFERENCES 1. Kofman O, Belmaker RH.

Psychopharmacology (Berl) 1993; 110(1 –2):229–234. 50. Einat H, Kofman O, Itkin O, et al. Augmentation of lithium’s behavioral effect by inositol uptake inhibitors. J Neural Transm 1998; 105(1):31– 38. 51. Berridge MJ, Irvine RF. Inositol phosphates and cell signalling. Nature 1989; 341(6239): 197 –205. 52. Nestler EJ, Gould E, Manji H, et al. Preclinical models: status of basic research in depression. Biol Psychiatry 2002; 52(6):503–528. 53. Willner P. The validity of animal models of depression.

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