Atypical Antipsychotics (Medical Psychiatry) by John C. Csernansky, John Lauriello

By John C. Csernansky, John Lauriello

Showcasing the newest reviews within the box, this reference unveils fresh breakthroughs within the use of abnormal antipsychotics for the remedy of numerous sufferer populations-tracking advancements within the administration of sufferers with schizophrenia and affective psychotic problems, in addition to healing regimens for kids and teens.

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Extra resources for Atypical Antipsychotics (Medical Psychiatry)

Example text

Thus, although a balanced antagonism of 5-HT2A serotonin and D2-dopamine receptors provides a reliable template to produce “atypical” antipsychotic drugs, other targeting strategies are also Table 7 Classification of Atypical Antipsychotic Drugs Based on Pharmacological Mechanism 5-HT2A/D2 D2/D3 D2 partial agonist 5-HT2A inverse agonists Drug Risperidone; ziprasidone; olanzapine; quetiapine; clozapine Amisulpride; remoxipride Aripiprazole M100907; SR46349B Extrapyramidal side effects Varies from absent (clozapine; quetiapine) to high (risperidone) Moderately low Low to absent None Weight gain liabilities Varies from low (ziprasidone) to high (clozapine, olanzapine) Moderately low Low None Low Low Low/none Anticholinergic/orthostasis Varies likely to be successful.

Curr Top Med Chem 2002; 2(6):507– 528. 36. Newman-Tancredi A, et al. Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol 1998; 355(2– 3):245–256. 37. Roth BL, Ciaranello RD, Meltzer HY. Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors. J Pharmacol Exp Ther 1992; 260 (3):1361–1365. 38. Rauser L, et al. Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.

M-100907 (Aventis). Curr Opin Investig Drugs 2001; 2(1): 123–732. 125. Roth BL, Sheffler D, Potkin SG. Atypical antipsychotic drug actions: unitary or multiple mechanisms for “atypicality”? Clin Neurosci Res 2003; 3:108–117. 126. Roth BL, Hanizavareh SM, Blum AE. Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology (Berl) Dec 2, 2003. e-pub ahead of print. 127. Kroeze WK, Hufeisen SJ, Popadak BA, et al.

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